Liver fibrosis markers of nonalcoholic steatohepatitis

Table 3 Glycated albumin-to-glycated hemoglobin ratio (GA/HbA1c ratio) and liver fibrosis

Patients	Cohort	Main results	Ref.
Various CLDs	82	The GA/HbA1c ratio was associated with hepatic functions (decreasing hepaplastin test and cholinesterase levels) independent of the mean plasma glucose levels	Bando et al[70], 2009
HCV-positive CLD	142	The GA/HbA1c ratio increased in association with the histological severity of liver fibrosis. The diagnostic performance of APRI improved when combined with the GA/HbA1c ratio	Aizawa et al[72], 2012
HBV-positive CLD	176	The GA/HbA1c ratio increased in line with the severity of fibrosis. The GA/HbA1c ratios were inversely correlated with four variables of liver function (the prothrombin time percentage, platelet count, albumin value and cholinesterase value)	Enomoto et al[73], 2014
NASH	36	The GA/HbA1c ratio was negatively correlated with ALT and platelet count. The GA/HbA1c ratio was positively correlated with the degree of liver fibrosis	Bando et al[74], 2012

CLDs: Chronic liver diseases; HCV: Hepatitis C virus; HBV: Hepatitis B virus; NASH: Nonalcoholic steatohepatitis.