Copyright
©The Author(s) 2015.
World J Gastroenterol. Jun 28, 2015; 21(24): 7427-7435
Published online Jun 28, 2015. doi: 10.3748/wjg.v21.i24.7427
Published online Jun 28, 2015. doi: 10.3748/wjg.v21.i24.7427
Table 1 General liver fibrosis markers for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
Biomarkers | Items | Cohort | AUROC for diagnosis | Ref. |
General markers for liver fibrosis (solo makers) | ||||
Hyaluronic acid | 112 | Stage 1-4: 0.80, Stage3-4: 0.80 | Sakugawa et al[38], 2005 | |
Type IV collagen 7S | 112 | Stage 1-4: 0.83, Stage3-4: 0.82 | Sakugawa et al[38], 2005 | |
Platelet count | 1048 | Stage 3-4: 0.77, Stage4: 0.92 | Yoneda et al[39], 2011 | |
General markers for liver fibrosis (algorithm based makers) | ||||
FibroTest | α2-macroglobulin, apolipoprotein A1, haptoglobin, GGT, bilirubin | 267 | Stage 2-4: 0.81, Stage 4: 0.88 | Ratziu et al[44], 2006 |
APRI | AST, platelet count | 111 | Stage 3-4: 0.85 | Kruger et al[41], 2011 |
FIB4 index | Age, AST, ALT, platelet count | 541 | Stage 3-4: 0.802 | Shah et al[43], 2009 |
ELF (enhanced liver fibrosis panel) | HA, TIMP1, P3NP | 192 | Stage 2-4: 0.82, Stage 3-4: 0.9 | Guha et al[40], 2008 |
- Citation: Enomoto H, Bando Y, Nakamura H, Nishiguchi S, Koga M. Liver fibrosis markers of nonalcoholic steatohepatitis. World J Gastroenterol 2015; 21(24): 7427-7435
- URL: https://www.wjgnet.com/1007-9327/full/v21/i24/7427.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i24.7427