Liver fibrosis markers of nonalcoholic steatohepatitis

Table 1 General liver fibrosis markers for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

Biomarkers	Items	Cohort	AUROC for diagnosis	Ref.
General markers for liver fibrosis (solo makers)
Hyaluronic acid		112	Stage 1-4: 0.80, Stage3-4: 0.80	Sakugawa et al[38], 2005
Type IV collagen 7S		112	Stage 1-4: 0.83, Stage3-4: 0.82	Sakugawa et al[38], 2005
Platelet count		1048	Stage 3-4: 0.77, Stage4: 0.92	Yoneda et al[39], 2011
General markers for liver fibrosis (algorithm based makers)
FibroTest	α2-macroglobulin, apolipoprotein A1, haptoglobin, GGT, bilirubin	267	Stage 2-4: 0.81, Stage 4: 0.88	Ratziu et al[44], 2006
APRI	AST, platelet count	111	Stage 3-4: 0.85	Kruger et al[41], 2011
FIB4 index	Age, AST, ALT, platelet count	541	Stage 3-4: 0.802	Shah et al[43], 2009
ELF (enhanced liver fibrosis panel)	HA, TIMP1, P3NP	192	Stage 2-4: 0.82, Stage 3-4: 0.9	Guha et al[40], 2008

APRI: AST-to-platelet ratio index.