Paeoniflorin inhibits human gastric carcinoma cell proliferation through up-regulation of microRNA-124 and suppression of PI3K/Akt and STAT3 signaling

Figure 12 Anti-microRNA-124 and the effect of paeoniflorin. Anti-microRNA (miR)-124 can reverse the effect of paeoniflorin on the expression of miR-124 in MGC-803 cells (A); After treatment with paeoniflorin (20 μmol/L) for 72 h, anti-miR-124 significantly promoted the cell proliferation of MGC-803 cells (B); After treatment with paeoniflorin (20 μmol/L) for 72 h, anti-miR-124 markedly inhibited cell apoptosis of MGC-803 cells (C); The anti-miR-124 significantly increased the expressions of PI3K, p-Akt, Akt and p-STAT3 protein in MGC-803 cells after paeoniflorin (20 μmol/L) treatment at 72 h (D). ^aP < 0.01 vs 0 μmol/L paeoniflorin treatment group and ^cP < 0.01 vs paeoniflorin-treated group transfected with negative control.