Protective effect of bicyclol against bile duct ligation-induced hepatic fibrosis in rats

Figure 2 Effects of bicyclol on liver fibrosis of bile duct ligation rats. Bile duct ligation (BDL) group consisted of animals submitted to undergo BDL operative manipulation and sham-operated animals were used as healthy control. BDL rats were divided into two groups, which orally received sterilized PBS or bicyclol [100 mg/(kg·d)] for consecutive 14 d. Liver sections were stained by Sirius red-stained sections (magnification × 200) (A) and quantified by blinded assessment (B). Hydroxyproline was assayed with frozen liver tissues (C). Data are expressed as mean ± SD of 6 animals per group. ^aP < 0.05 vs Sham group; ^cP < 0.05 vs BDL group. Sham: Sham group; BDL: BDL group; BDL-Bic: Bicyclol group.