Novel therapeutic approaches for hepatitis B virus covalently closed circular DNA

doi:10.3748/wjg.v21.i23.7084

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Jun 21, 2015 (publication date) through Jan 11, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 21, 2015; 21(23): 7084-7088
Published online Jun 21, 2015. doi: 10.3748/wjg.v21.i23.7084

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Figure 2 Life cycle of hepatitis B virus. After hepatitis B virus (HBV) virions infect hepatocytes, relaxed circular DNA (rcDNA) enters the nucleus and is converted to covalently closed circular HBV DNA (cccDNA). HBV cccDNA persists in the nucleus as a mini-chromosome. HBV pregenomic RNA (pgRNA) is transcribed from cccDNA and acts as the viral protein mRNA. HBV pgRNA is co-packaged with reverse transcriptase in capsids and is reverse-transcribed into rcDNA. Nucleocapsids containing rcDNA are released from the host cell as virions.

Citation: Ohno M, Otsuka M, Kishikawa T, Yoshikawa T, Takata A, Koike K. Novel therapeutic approaches for hepatitis B virus covalently closed circular DNA. World J Gastroenterol 2015; 21(23): 7084-7088
URL: https://www.wjgnet.com/1007-9327/full/v21/i23/7084.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i23.7084