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©The Author(s) 2015.
World J Gastroenterol. Jun 21, 2015; 21(23): 7065-7073
Published online Jun 21, 2015. doi: 10.3748/wjg.v21.i23.7065
Published online Jun 21, 2015. doi: 10.3748/wjg.v21.i23.7065
Figure 1 Structure of neuropilin-1 and neuropilin-2.
These proteins contain five extracellular domains, a single-pass TMD domain, and a short cytosolic tail that lacks tyrosine kinase activity. SEMA3s bind to the a1/a2/b1 segment, and Vascular endothelial growth factors (VEGFs) bind to b1/b2. The binding sites of other growth factors are not well characterized, but HGF, B-FGF, TGF-β1 were recently reported to bind both NRPs. The c domain contributes to receptor dimerization with the transmembrane domain.
- Citation: Elpek G&. Neuropilins and liver. World J Gastroenterol 2015; 21(23): 7065-7073
- URL: https://www.wjgnet.com/1007-9327/full/v21/i23/7065.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i23.7065