High level of intercellular adhesion molecule-1 affects prognosis of patients with hepatocellular carcinoma

Table 3 Association between intercellular adhesion molecule-1 level, clinical parameters and disease-free survival/overall survival

Clinical character	Category	Number of patients	Disease-free survival (mo)			Overall survival (mo)
			mean	95%CI	P value	mean	95%CI	P value
ICAM-1 (ng/mL)	≤ 684	52	58.18	44.77-71.58	0.003	64.57	52.14-77.01	0.002
	> 684	184	36.96	30.51-43.40		42.75	36.48-49.01
Age (yr)	≤ 55	161	40.37	33.32-47.43	0.325	45.89	39.05-52.74	0.262
	> 55	75	45.38	34.62-56.14		51.57	41.37-61.77
Gender	Female	29	57.84	38.90-76.78	0.066	62.96	43.72-82.19	0.076
	Male	207	39.73	33.60-45.86		44.66	38.58-50.74
Family history	No	203	39.83	33.62-46.05	0.077	45.69	39.68-51.69	0.092
	Yes	33	53.83	37.30-70.36		59.63	43.90-75.36
HBsAg	Negative	34	47.54	30.65-64.43	0.501	52.62	36.64-68.60	0.462
	Positive	202	40.74	34.47-47.01		46.72	40.65-52.79
AFP (ng/mL)	≤ 100	99	46.01	36.52-55.49	0.286	52.18	43.07-61.28	0.214
	> 100	137	39.00	31.53-46.47		44.75	37.51-51.99
Tumor size (cm)	≤ 5	32	70.51	53.82-87.19	< 0.001	77.42	62.56-92.28	< 0.001
	> 5	204	37.57	31.49-43.66		43.36	37.44-49.28
Cirrhosis	No	25	34.60	17.57-51.64	0.190	39.16	22.83-55.49	0.237
	Yes	211	42.81	36.53-49.09		48.83	42.77-54.89
Tumor number	Single	149	50.25	42.28-58.21	< 0.001	55.27	47.66-62.87	< 0.001
	Multiple	87	27.72	20.32-35.12		34.92	27.37-42.48
NLR	≤ 2.31	130	53.58	45.00-62.17	< 0.001	59.00	50.88-67.12	< 0.001
	> 2.31	106	27.50	20.58-34.43		34.23	27.17-41.29
TNM stage	I-II	108	59.65	50.13-69.18	< 0.001	66.86	58.17-75.54	< 0.001
	III-IV	128	27.17	20.87-33.46		31.88	25.56-38.21
PVTT	No	184	47.62	40.59-54.64	< 0.001	54.25	47.61-60.90	< 0.001
	Yes	52	22.06	13.88-30.24		24.73	16.55-32.91
Distant metastasis	No	217	42.85	36.62-49.08	0.313	48.89	42.90-54.88	0.166
	Yes	19	26.79	14.76-38.82		31.21	18.29-44.13
Recurrence	No					44.59	36.73-52.46	0.051
	Yes					51.58	43.77-59.39

ICAM-1: Intercellular adhesion molecule-1; HBsAg: Hepatitis B surface antigen; AFP: Alpha-fetoprotein; NLR: Neutrophil-to-lymphocyte ratio; TNM: Tumor-node-metastasis; PVTT: Portal vein tumor thrombus.