&beta;-2 Adrenergic receptor gene polymorphism and response to propranolol in cirrhosis

doi:10.3748/wjg.v21.i23.7191

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 21, 2015; 21(23): 7191-7196
Published online Jun 21, 2015. doi: 10.3748/wjg.v21.i23.7191

Table 2 Heart rate and VP changes after propranolol according to β₂-AR gene polymorphisms

Variables	Gly¹⁶-Glu/Gln²⁷ (n = 19)		Compound heterozygotes (n = 38)		Arg¹⁶-Gln²⁷ (n = 7)
Variables	Baseline	7 d	Baseline	7 d	Baseline	7 d
HR (beats/min)	76.3 ± 2.7	60.5 ± 1.8^b	75.6 ± 4.9	62.5 ± 3.6^b	74.1 ± 4.7	62.9 ± 3.0^a
VP(mmHg)	21.35 ± 3.02	16.52 ± 1.87^b	22.08 ± 3.26	19.43 ± 3.12^a	21.69 ± 2.78	18.79 ± 3.15^b

^aP < 0.05,

^bP < 0.01 vs baseline. HR: Heart rate.

Citation: Kong DR, Wang JG, Sun B, Wang MQ, Chen C, Yu FF, Xu JM. β-2 Adrenergic receptor gene polymorphism and response to propranolol in cirrhosis. World J Gastroenterol 2015; 21(23): 7191-7196
URL: https://www.wjgnet.com/1007-9327/full/v21/i23/7191.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i23.7191