Detection of superficial esophageal squamous cell neoplasia by chromoendoscopy-guided confocal laser endomicroscopy

Figure 3 Confocal laser endomicroscopy images showing different intraepithelial papillary capillary loop changes in the esophageal lesions. A: Regular squamous esophageal epithelium with regular intraepithelial papillary capillary loops (IPCLs) and epithelial cells; B: Some tortuous IPCLs are seen in the non-neoplastic inflammatory lesion; C: Various shapes of twisted IPCLs (red arrow) are seen in the low-grade intraepithelial neoplasia lesion; D: Obvious caliber and shape changes with a larger diameter IPCL (blue arrow) are seen in the high-grade intraepithelial neoplasia lesion; E: Tumor vessels (yellow arrow) are seen in esophageal squamous cell carcinoma.