Efficacy of poly-unsaturated fatty acid therapy on patients with nonalcoholic steatohepatitis

Table 2 Comparison of parameters 6 mo later

Variables	Controlled	PUFA	P value
n	39	39
BMI (kg/m2)	26.4 ± 1.0	25.8 ± 1.2	0.065
Smoking, n (%)	15 (38.5)	14 (35.9)	0.278
ALT (U/L)	80.4 ± 7.6	67.8 ± 5.3	< 0.01
AST (U/L)	75.6 ± 5.8	60.3 ± 6.8	< 0.01
Bilirubin, total (md/dL)	0.8 ± 0.2	0.7 ± 0.2	0.343
Bilirubin, direct (md/dL)	0.6 ± 0.1	0.6 ± 0.2	0.338
FBG (mmol/L)	5.9 ± 0.2	5.9 ± 0.3	0.285
TG (mmol/L)	2.4 ± 0.4	1.8 ± 0.3	0.015
TC (mmol/L)	5.2 ± 0.6	4.7 ± 0.3	0.040
LDL-C (mmol/L)	3.5 ± 0.5	3.1 ± 0.6	0.062
HDL-C (mmol/L)	1.1 ± 0.3	1.3 ± 0.4	0.105
CRP (mg/L)	9.2 ± 0.8	7.6 ± 0.4	0.045
MDA (nmol/mL)	0.6 ± 0.1	0.4 ± 0.2	0.048
Type IV collagen (ng/mL)	4.6 ± 0.7	3.5 ± 0.5	0.023
P-III-P (U/mL)	0.8 ± 0.2	0.5 ± 0.3	0.039
Weekly exercise time (min)	107.6 ± 12.3	109.5 ± 10.4	0.272

ALT: Alanine aminotransferase; AST: Aspartase aminotransferase; BMI: Body mass index; PUFA: Poly-unsaturated fatty acid; MDA: Malondialdehyde; LDL-C: Lipoprotein-cholesterol; HDL-C: High-density lipoprotein-cholesterol; CRP: C-reactive protein; FBG: Fasting blood glucose; TG: Triglyceride; TC: Total cholesterol.