Prevalence, significance and predictive value of antiphospholipid antibodies in Crohn’s disease

Table 5 Univariate Kaplan Meier and Log-rank analysis of serologic and clinical factor associated with complicated disease course in B1 Crohn’s disease patients (n = 143)

Variable	Internal penetrating and/or stricturing complication		Perianal penetrating complication		CD-related abdominal surgery
	HR (95%CI)	PLogRank-value	HR (95%CI)	PLogRank-value	HR (95%CI)	PLogRank-value
Gender - male	1.10 (0.47-2.55)	0.83	2.69 (0.80-9.03)	0.11	0.91 (0.33-2.55)	0.86
Smoking	3.72 (1.23-11.21)1	0.021	1.61 (0.36-7.19)	0.53	1.64 (0.45-5.97)	0.45
Location (colon only)	0.41 (0.17-0.96)1	0.041	1.00 (0.29-3.43)	0.99	0.61 (0.22-1.74)	0.36
Frequent relapse	1.10 (0.39-3.07)	0.85	7.29 (1.72-30.99)1	0.0071	1.64 (0.44-6.10)	0.46
APLA at all	1.36 (0.59-3.16)	0.47	1.30 (0.40-4.27)	0.66	1.37 (0.49-3.80)	0.55
Anti-β2-GPI at all	0.56 (0.13-2.32)	0.42	0.99 (0.13-7.70)	0.99	0.33 (0.06-1.81)	0.20
ACA at all	0.41 (0.13-1.26)	0.12	1.12 (0.23-5.49)	0.89	0.30 (0.07-1.27)	0.10
Anti-PS/PT at all	1.07 (0.39-2.97)	0.89	1.74 (0.38-8.03)	0.48	1.11 (0.29-4.18)	0.88

¹The P_LogRank-value < 0.05. APLA: Antiphospholipid antibodies; β2-GPI: Beta2-glycoprotein-I; ACA: Anti-cardiolipin antibody; PS/PT: Phosphatidylserine/prothrombin complex.