Advances in the study of Lynch syndrome in China

Table 2 Frequency of extra colonic cancer related with hereditary nonpolyposis colorectal cancer in China n (%)

Ref.	Extra colonic cancer			n	Diagnostic criteria	Hospital location
[73]	Lung	Gastric	Endometrial		ACII	Liaoning
	56 (20.07)	48 (17.20)	32 (11.47)	279
[52]	Gastric	Glioma	Cardiac/retinoblastoma/ovarian		ACII, JC	Beijing
	13 (41.90)	3 (9.68)	2/2/2 (6.45)	31
[53]	Gastric	Endometrial	Esophagus		ACII, JC, BG	Beijing
	18 (28.13)	11 (17.19)	7 (10.94)	64
[63]	Endometrial	Brest	Lung/Gastric		ACI, ACII, JC	Tianjin
	9 (19.57)	7 (15.22)	6/6 (13.04)	46
[69]	Gastric	Endometrial/Lung/Brest/Bladder			ACI, ACII	Guangdong
	5 (31.25)	2/2/2/2 (1.63)		16
[55]	Gastric	Liver	Endometrial		ACI, ACII, JC, BG	Shanghai
	16 (18.60)	10 (11.63)	8 (9.30)	86
[54]	Gastric	Endometrial	Liver		ACI, ACII	Shanghai
	8 (25.00)	8 (25.00)	5 (15.63)	32
[70]	Gastric	Endometrial	Liver		ACI	Shanghai
	25 (39.68)	11 (17.46)	6 (9.52)	63
[72]	Gastric	Esophagus	Mouth		Chinese C	Zhejiang
	9 (37.50)	3 (12.50)	2 (8.33)	24

ACI: Amsterdam criteria I; ACII: Amsterdam criteria II; JC: Japanese criteria; CC: Chinese criteria; BG: Bethesda guideline.