Precore/basal core promoter mutants quantification throughout phases of hepatitis B virus infection by Simpleprobe

Figure 1 Precore, basal core promoter mutation distribution throughout phases of hepatitis B virus infection. Log₁₀ precore, log₁₀ basal core promoter value (A, B), precore%, basal core promoter (%) (C, D) distribution through the phases of hepatitis B virus infection; disease progression can be estimated by the combination of log₁₀ precore, log₁₀ basal core promoter and precore%, basal core promoter (%) (E). PC: Precore; BCP: Basal core promoter; IT: Immune tolerance; IC: Immune clearance; LR: Low-replicative; ENH: HBeAg-negative hepatitis; HBeAg: Hepatitis B early antigen; PC%: PC mutant quantity per total viral load; BCP%: BCP mutant quantity per total viral load.