Loss of Dicer1 impairs hepatocyte survival and leads to chronic inflammation and progenitor cell activation

Figure 8 Spontaneous hepatocarcinogenesis in the Dicer1-deficient liver. A: Hepatocellular carcinomas in Albumin-Cre; Dicer1^fl/fl mice at 4 and 12 mo after birth (Scale bar: 1 cm). Hematoxylin-eosin staining and PAS staining of the Dicer1-deficient liver tumors (Scale bar: 100 μm); B: Summary of incidence and characteristics of the tumors that developed in 4- to 12-mo-old mutant mice; C, D: Dicer1 immunohistochemistry (Scale bar: 100 μm) and Western blotting were performed respectively to detect the Dicer1 expression level in HCC; E: The roles of hepatocyte death, inflammation and fibrosis in the histological processes of hepatocarcinogenesis in the Dicer1-deficient liver.