Loss of Dicer1 impairs hepatocyte survival and leads to chronic inflammation and progenitor cell activation

Figure 7 Activation of liver progenitor cells in the mutant liver. A: Immunofluorescence of CK19, CD133 and OV6 in the 1-mo-old mutant liver section exhibits a robust ductular reaction (Scale bar: 200 μm); B: Immunofluorescence of SOX2 and OCT4 in 1-mo-old Dicer1^-/- liver shows a large numbers of SOX2- and OCT4-positive cells both in the portal areas and parenchyma (Scale bar: 100 μm); C: Pluripotency transcription factors gene expression was shown for each gene as percent of expression in Dicer1^-/- mice compared with control littermates (mean ± SD; n = 4), ^aP < 0.05 vs wild-type mice.