Loss of Dicer1 impairs hepatocyte survival and leads to chronic inflammation and progenitor cell activation

Figure 6 Chronic fibrosis in the Dicer1-deficient liver. A: Masson staining showed remarkable liver fibrosis in Dicer1-deficient livers (Scale bar: 100 μm); B: Hepatic stellate cells were highly activated in Dicer1-deficient mice liver; C: The relative gene expression of fibrogenic markers, including TGF-β, Col1a1, Col4a1 and HGF, was determined by qPCR (mean ± SD; n = 4-6); ^aP < 0.05 vs wild-type mice.