Loss of Dicer1 impairs hepatocyte survival and leads to chronic inflammation and progenitor cell activation

Figure 5 Dicer1-deficient liver develops chronic inflammation. A: Hematoxylin-eosin staining show remarkable liver inflammation in Dicer1-deficient livers (Scale bar: 100 μm); B: Intrahepatic inflammation cells was determined by flow cytometric analysis for the pan-leucocyte marker CD45 in 2-mo-old mice (mean ± SD; n = 4-6), ^aP < 0.05 vs wild-type mice; C: Serum cytokine concentrations were determined by Luminex assay, Dicer1-deficient mice expressed significantly higher level of IL-1β, IL-6, MCP-1, and TNF-α (mean ± SD; n = 4-6), ^aP < 0.05 vs wild-type mice.