Loss of Dicer1 impairs hepatocyte survival and leads to chronic inflammation and progenitor cell activation

Figure 4 Dicer1^-/- liver displays increased hepatocyte death and compensatory proliferation. A: Significant hepatocyte apoptosis and proliferation in the Dicer1-deficient liver (Scale bar: 100 μm); B: Quantification of hepatocyte apoptosis (TUNEL staining) and proliferation (Ki67 immunohistochemistry) in Dicer1-deficient liver (mean ± SD; n = 4-5), ^aP < 0.05 vs wild-type mice; C: Western blot analysis of the liver tissue lysates with indicated antibodies. GAPDH was used as an internal control.