Loss of Dicer1 impairs hepatocyte survival and leads to chronic inflammation and progenitor cell activation

Figure 3 Increased necrotic area in the Dicer1^-/- liver. A: Hematoxylin-eosin stained liver tissue from Dicer1^-/- mouse shows necrosis (Scale bar: 200 μm). The necrotic area is circled with black dotted lines; B: Quantitative analysis of necrotic area observed on HE stained sections (mean ± SD; n = 4-5), ^aP < 0.05 vs wild-type mice; C: ALT and AST serum levels in the wild-type and Dicer1-deficient mice at indicated time points (mean ± SD; n = 4-6), ^aP < 0.05 vs wild-type mice; D: IL-1α expression in Dicer1^-/- liver was compared with control littermates (mean ± SD; n = 4), ^aP < 0.05 vs wild-type mice. ALT: Alanine amino-transferase; AST: Aspartate amino-transferase.