Nocardia infections among immunomodulated inflammatory bowel disease patients: A review

Table 3 Clinical cases of nocardia disease in inflammatory bowel disease patients: Literature review

Ref.	IBD	Age (yr)	Sex	Medication	N. species	Clinical form	Treatment(duration)	Evolution
Vohra et al[40]	CD	16	F	6-Mercaptopurine 6 wk steroids	N. asteroids	Brain abcess; calf abscess	TMP-SMX + ceftriaxon: not established	Favourable
Stack et al[41]	UC	68	M	Cyclosporine, steroids	N. asteroids	Pulmonary (abcess)	Amikacin + cefotaxime-3 wk followed by cefuroxime 3 mo	Favourable
Singh et al[30]	CD	45	M	Infliximab 6 wk	N. spp. (polymerase chain reaction)	Cutaneous	TMP-SMX, 3 yr	Favourable
Stratakos et al[33]	CD (DM)	77	F	Infliximab 8 mo, steroids	N asteroids (+Pneumocystis jiroveci)	Pulmonary	TMP-SMX, 6 mo	Favourable
Parra et al[34]	CD	53	F	Infliximab, azathioprine, steroids	N. cyriacigeorgica	Pulmonary	TMP-SMX + amikacin + imipnem - 6 wk followed by TMP-SMX, 7.5 mo	Favourable
Arora et al[42]	UC	61	F	Azathioprine, steroids	N. nova	Cutaneous, abscess: brain lung, renal, pancreatic	TMP-SMX, 1 yr	Favourable, remission 2 yr after treatment
Nakahara et al[36]	CD	23	M	Infliximab, < 3 wk, steroids	N. farcinia	Liver nocardiosis	TMP-SMX for? not known	Favourable
Ali et al[31]	CD	61	M	Infliximab > 1 yr	N. spp.	Cutaneous	TMP-SMX for 6 mo	Favourable, restarted anti-TNF after therapy
Saleemuddin et al[35]	CD	81	M	Infliximab (3 mo) 6-mercapto-purine	Nocardia spp.	Pulmonary	TMP-SMX for? not known	Favourable; 5 mo after restarted anti-TNF under TMP-SMX; ok 1 yr after diagnosis
Sidney et al[49]	CD	73	F	Infliximab (5 infusions) Prednisolone methotrexate	Nocardia asteroids	Disseminated: Pulmonary cerebral	TMP-SMX for? not known	Favourable with sequelae

TMP-SMX: Trimethoprim- sulfamethoxazole; DM: Diabetes mellitus; CD: Crohn's disease; UC: Ulcerative colitis.