Short-term and long-term risk factors in gastric cancer

Table 1 Prognostic significance of different risk factors in the first two years of follow-up and thereafter

	First 2 years of follow-up		Subsequent years
	HR (95%CI)	P value	HR (95%CI)	P value
Centre (Siena vs Verona)	0.62 (0.44-0.88)	0.006	1.82 (1.06-3.14)	0.029
Sex (women vs men)	0.69 (0.49-0.97)	0.028	0.79 (0.48-1.30)	0.345
Age		< 0.001		0.586
65-74 yr vs < 65 yr	1.67 (1.14-2.44)		1.18 (0.68-2.04)
≥ 75 yr vs < 65 yr	2.28 (1.50-3.46)		0.81 (0.38-1.72)
Site (body/antrum vs fundus)	0.84 (0.60-1.18)	0.318	0.30 (0.18-0.51)	< 0.001
Histology (mix/diff vs intest)	0.80 (0.57-1.12)	0.198	1.91 (1.09-3.36)	0.023
T stage		< 0.001		0.043
T3 vs T2	1.69 (0.82-3.50)		1.25 (0.59-2.68)
T4a vs T2	3.13 (1.60-6.13)		2.21 (1.10-4.44)
T4b vs T2	5.14 (2.34-11.27)		3.26 (0.87-12.17)
N stage		< 0.001		0.007
N1 vs N0	1.49 (0.70-3.14)		0.92 (0.35-2.40)
N2 vs N0	3.47 (1.94-6.22)		2.55 (1.29-5.03)
N3 vs N0	5.28 (3.09-9.04)		2.36 (1.22-4.57)
Lymphadenectomy: D3 vs D2	0.94 (0.66-1.33)	0.717	0.92 (0.54-1.57)	0.753

P values were computed by the LR test. Hazard ratios (HR) were computed by a Cox regression model, controlling for all the other variables in the model.