Integrative analysis of aberrant Wnt signaling in hepatitis B virus-related hepatocellular carcinoma

Figure 2 TP53 GOF mutation does not likely contribute to the aberrant activation of Wnt signaling. A: TP53 GOF mutants activate Wnt signaling in vitro; B: TP53 mutation rate in different tumors and different etiologies of HCC. Although TP53 mutation was commonly detected in HCC, GOF mutation was a rare event in HCC with different etiologies. ESCC: Esophageal squamous cell carcinoma; GOF: Gain-of-function; HBV: Hepatitis B virus; HCV: Hepatitis C virus; HCC: Hepatocellular carcinoma.