SGK1 inhibits cellular apoptosis and promotes proliferation via the MEK/ERK/p53 pathway in colitis

Figure 4 Serum-and-glucocorticoid-inducible-kinase-1 expression levels in tumor necrosis factor-treated intestinal epithelial cells assessed with western blotting. A, B: SGK1 expression levels at different times and doses of TNF in HCT-116 cells; C, D: SGK1 expression levels at different times and doses of TNF in IEC-6 cells. ^aP < 0.05 and ^bP < 0.01 represented 24 h vs 0 h after TNF-treatment or 10 ng vs 5 ng TNF. GAPDH served as the internal control. SGK1: Serum-and-glucocorticoid-inducible-kinase-1; TNF: Tumor necrosis factor; IECs: Intestinal epithelial cells.