SGK1 inhibits cellular apoptosis and promotes proliferation via the MEK/ERK/p53 pathway in colitis

Figure 2 2,4,6-trinitrobenzene sulfonic acid and ethanol colitis model was successfully established. The macroscopic appearance of the colon in TNBS-treated BALB/c mice. A: The colons were obtained 72 h after intra-rectal TNBS or ethanol treatment and were then photographed; B: TNBS or ethanol (the control group) administration caused variation in bodyweight in the murine model; C: Mean colon length; D, E: The DAI and HAI of mice treated with TNBS or ethanol were assessed. Data are presented as the mean ± SD (n = 4). One of three representative experiments is shown. ^aP < 0.05 and ^bP < 0.01 vs the ethanol treatment group. TNBS: 2,4,6-trinitrobenzene sulfonic acid.