Thrombospondin peptide ABT-898 inhibits inflammation and angiogenesis in a colitis model

Figure 3 Interleukin-6 protein levels in plasma of mice under dextran sodium sulfate-induced colitis. Interleukin (IL)-6 levels were analyzed using sandwich-based ELISA. Elevated levels of IL-6 were detected in WT and TSP-1^-/- plasma samples of mice treated with DSS for 7 d receiving saline injections (P = 0.0114). IL-6 was significantly diminished in plasma of TSP-1^-/- treated with the peptide (P = 0.0002) and WT samples under the same treatment (P = 0.0148). ^bP < 0.05 vs control. Error bars represent SEM. The results shown are representative of three or more independent experiments. TSP-1^-/-: TSP-1^-/- controls; TSP-1^-/-p; TSP-1^-/- with ABT-898 peptide; WT: WT control; WTp: WT treated with ABT-898 peptide.