Thrombospondin peptide ABT-898 inhibits inflammation and angiogenesis in a colitis model

Figure 1 Effects of the TSP-1 mimetic peptide ABT-898 in inflammation. Inflammation was graded by evaluating hematoxylin-eosin stained sections in a blindly fashion (A-D). Sections from colons of TSP-1^-/- mice with DSS and treated with 5% glucose (A), sections from colons of TSP-1^-/- mice treated with ABT-898 (B), colonic sections from WT mice treated with 5% glucose (C) and with the peptide ABT-898 only (D). The peptide ABT-898 significantly reduced the leukocytic infiltration in both, WT and TSP-1^-/- colitic lesions when compared with their controls (E). TSP-1^-/- mice controls (A) displayed more inflammation that WT controls (C). ^aP < 0.0001 and ^bP < 0.05 vs control. TSP-1^-/-: TSP-1^-/- controls; TSP-1^-/-p: TSP-1^-/-treated with the ABT-898 peptide; WT: WT control; WTp: WT treated with the ABT-898 peptide.