Proton pump inhibitors therapy vs H2 receptor antagonists therapy for upper gastrointestinal bleeding after endoscopy: A meta-analysis

doi:10.3748/wjg.v21.i20.6341

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World Journal of Gastroenterology

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1007-9327

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Meta-Analysis

World J Gastroenterol. May 28, 2015; 21(20): 6341-6351
Published online May 28, 2015. doi: 10.3748/wjg.v21.i20.6341

Table 2 Subgroup analyses of recurrent bleeding rate

	Number of studies	Number of subjects	OR (95%CI)	Heterogeneity withinsubgroups	Difference betweensubgroups
End-point time
Overall	10	2076	0.33 (0.24-0.45)	No (P = 0.20, I² = 23%)	No (P = 0.42, I² = 0%)
24 h	1	164	0.08 (0.00-1.46)	NA
3 d	2	249	0.23 (0.07-0.76)	Yes (P = 0.13, I² = 56%)
7 d	2	313	0.32 (0.13-0.79)	No (P = 0.37, I² = 0%)
14 d	3	464	0.26 (0.16-0.43)	Yes (P = 0.07, I² = 58%)
28-30 d	2	231	0.45 (0.15-1.36)	NA
6 wk or more	5	588	0.53 (0.30-0.94)	No (P = 0.42, I² = 0%)
Nation
Overall	10	1283	0.36 (0.25-0.51)	No (P = 0.13, I² = 35%)	No (P = 0.42, I² = 0%)
Japan	4	486	0.63 (0.33-1.17)	No (P = 0.51, I² = 0%)
China	3	402	0.25 (0.14-0.42)	Yes (P = 0.06, I² = 59%)
South Korea	2	246	0.25 (0.07-0.95)	NA
United States	1	149	0.45 (0.15-1.36)	NA
Intervention drug PPI
Overall	8	1030	0.32 (0.21-0.48)	No (P = 0.13, I² = 37%)	No (P = 0.93, I² = 0%)
Omeprazole	5	615	0.32 (0.20-0.52)	Yes (P = 0.03, I² = 61%)
Pantoprazole	3	415	0.31 (0.15-0.65)	No (P = 0.69, I² = 0%)
Intervention drug H₂RA
Overall	8	996	0.33 (0.22-0.48)	No (P = 0.14, I² = 36%)	No (P = 0.18, I² = 41.6%)
Cimetidine	3	430	0.27 (0.16-0.44)	Yes (P = 0.07, I² = 58%)
Famotidine	3	315	0.85 (0.28-2.61)	No (P = 0.56, I² = 0%)
Ranitidine	2	251	0.34 (0.14-0.85)	No (P = 0.45, I² = 0%)

OR: Odds ratio; CI: Confidence interval; NA: Not applicable.

Citation: Zhang YS, Li Q, He BS, Liu R, Li ZJ. Proton pump inhibitors therapy vs H₂ receptor antagonists therapy for upper gastrointestinal bleeding after endoscopy: A meta-analysis. World J Gastroenterol 2015; 21(20): 6341-6351
URL: https://www.wjgnet.com/1007-9327/full/v21/i20/6341.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i20.6341