Proton pump inhibitors therapy vs H2 receptor antagonists therapy for upper gastrointestinal bleeding after endoscopy: A meta-analysis

doi:10.3748/wjg.v21.i20.6341

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 21, Issue 20

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (10884)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-7) series, Tables (1-2) series.

Item

Count

PDF

831

WORD

236

HTML

6519

Figures (1-7)

192

Tables (1-2)

197

Sum=7975

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1190

Download

1719

Sum=2909

May 28, 2015 (publication date) through Nov 22, 2024

Times Cited of This Article

Times Cited (21)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Meta-Analysis

World J Gastroenterol. May 28, 2015; 21(20): 6341-6351
Published online May 28, 2015. doi: 10.3748/wjg.v21.i20.6341

Table 2 Subgroup analyses of recurrent bleeding rate

	Number of studies	Number of subjects	OR (95%CI)	Heterogeneity withinsubgroups	Difference betweensubgroups
End-point time
Overall	10	2076	0.33 (0.24-0.45)	No (P = 0.20, I² = 23%)	No (P = 0.42, I² = 0%)
24 h	1	164	0.08 (0.00-1.46)	NA
3 d	2	249	0.23 (0.07-0.76)	Yes (P = 0.13, I² = 56%)
7 d	2	313	0.32 (0.13-0.79)	No (P = 0.37, I² = 0%)
14 d	3	464	0.26 (0.16-0.43)	Yes (P = 0.07, I² = 58%)
28-30 d	2	231	0.45 (0.15-1.36)	NA
6 wk or more	5	588	0.53 (0.30-0.94)	No (P = 0.42, I² = 0%)
Nation
Overall	10	1283	0.36 (0.25-0.51)	No (P = 0.13, I² = 35%)	No (P = 0.42, I² = 0%)
Japan	4	486	0.63 (0.33-1.17)	No (P = 0.51, I² = 0%)
China	3	402	0.25 (0.14-0.42)	Yes (P = 0.06, I² = 59%)
South Korea	2	246	0.25 (0.07-0.95)	NA
United States	1	149	0.45 (0.15-1.36)	NA
Intervention drug PPI
Overall	8	1030	0.32 (0.21-0.48)	No (P = 0.13, I² = 37%)	No (P = 0.93, I² = 0%)
Omeprazole	5	615	0.32 (0.20-0.52)	Yes (P = 0.03, I² = 61%)
Pantoprazole	3	415	0.31 (0.15-0.65)	No (P = 0.69, I² = 0%)
Intervention drug H₂RA
Overall	8	996	0.33 (0.22-0.48)	No (P = 0.14, I² = 36%)	No (P = 0.18, I² = 41.6%)
Cimetidine	3	430	0.27 (0.16-0.44)	Yes (P = 0.07, I² = 58%)
Famotidine	3	315	0.85 (0.28-2.61)	No (P = 0.56, I² = 0%)
Ranitidine	2	251	0.34 (0.14-0.85)	No (P = 0.45, I² = 0%)

OR: Odds ratio; CI: Confidence interval; NA: Not applicable.

Citation: Zhang YS, Li Q, He BS, Liu R, Li ZJ. Proton pump inhibitors therapy vs H₂ receptor antagonists therapy for upper gastrointestinal bleeding after endoscopy: A meta-analysis. World J Gastroenterol 2015; 21(20): 6341-6351
URL: https://www.wjgnet.com/1007-9327/full/v21/i20/6341.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i20.6341