Integrative analysis of aberrant Wnt signaling in hepatitis B virus-related hepatocellular carcinoma

Table 8 Mutation case numbers and rates of TP53 in different tissues

Cancer type	GOF mutation cases (n)	Mutation cases (n)	Total cases (n)	GOF mutation rate (%)	Non-GOF mutation rate (%)	Total mutation rate (%)	P value1
HCC	91	825	2813	3.23	26.09	29.33
Colon adenocarcinoma	331	1867	3596	9.20	42.71	51.92	< 0.001
Ovary carcinoma	392	1604	3329	11.78	36.41	48.18	< 0.001
Stomach adenocarcinoma	270	1160	3459	7.81	25.73	33.54	< 0.001
Lung adenocarcinoma	421	2414	6394	6.58	31.17	37.75	< 0.001
ESCC	224	972	1858	12.06	40.26	52.31	< 0.001

¹GOF mutation rate vs HCC. ESCC: Esophageal squamous cell carcinoma; GOF: Gain-of-function; HCC: Hepatocellular carcinoma.