New targeted therapies in pancreatic cancer

Table 2 Potential therapeutic targets using miRNA

Ref.	miRNA	Oncogene/tumor suppressor	Target genes	Cellular process affected
Moriyama et al[99], 2009	miR-21	Oncogene	CDK6, PDCD4, CDKN1A, FAS, IL6R, SOCS5, APAF1, NFlB, TPM1	Apoptosis, cell proliferation, cell invasion
Park et al[94], 2009	miR-221	Oncogene	CDKN1B, CDKN1C, KIT	Cell migration, proliferation
Habbe et al[100], 2009	miR-155	Oncogene	AGTR1, APC, ARID2, BACH1, CEBPB, CYR61, DET1, EDN1, ETS1, FADD, FGF7, FOXO3	Cell migration
Chen et al[101], 2011	miR-196a	Oncogene	NRAS, HOXB8, HMGA2, ANXA1	Cell growth and differentiation
Cai et al[95], 2013	miR-181b	Oncogene	BCL2	Sensitization to gemcitabine
Yan et al[96], 2010	miR-20a	Oncogene	STAT3, CDH1	Proliferation and invasion
Torrisani et al[102], 2009	Let-7	Tumor suppressor	KRAS, HMGA2, TRIM71, NF2	Cell proliferation
Ji et al[98], 2009	miR-34a	Tumor suppressor	NOTCH1, BCL2, E2F3, VEGFA, SIRT1, CCND1, CDK6	Apoptosis, cell proliferation
Zhao et al[103], 2010	miR-217	Tumor suppressor	KRAS, SIRT1, PTEN	Cell proliferation, invasion
Yu et al[97], 2010	miR-96	Tumor suppressor	KRAS	Invasion, cell migration, apoptosis
Li et al[104], 2010	miR-146a	Tumor suppressor	EGFR	Invasion
Hou et al[105], 2012	miR-216a	Tumor suppressor	PTEN, CDC42, CD44, SIRT1	Tumorigenicity