Increased density of tolerogenic dendritic cells in the small bowel mucosa of celiac patients

Figure 4 Densities of IDO⁺ DCs on paraffin sections for the different study groups (A); Spearman’s rank correlation between the histological grades (according to Marsh) and IDO⁺ DCs (on paraffin sections) for the studied persons (B); between the densities of IDO⁺ DCs and serum IgA-tTG levels in the studied persons (C); or between the densities of IDO⁺ DCs and FOXP3⁺ Treg cells for the entire study group, evaluated on paraffin sections (r = 0. 76; P = 0.0001) (D). The dots represent the mean values of positively stained cells per microscopic field. ^bP < 0.01, CD vs normal mucosa; ^dP < 0.01, CD with T1D vs normal mucosa; ^fP < 0.01, CD total vs normal mucosa. CD: Celiac disease; DC: Dendritic cell; T1D: Type 1 diabetes; IgA-tTG: IgA antibody; Tregs: regulatory T cells; IDO: Indoleamine 2,3-dioxygenase.