Increased density of tolerogenic dendritic cells in the small bowel mucosa of celiac patients

Figure 2 Density of CD11c⁺ dendritic cells (A), FOXP3⁺ regulatory T cells (B) in paraffin sections for the different study groups; Spearman’s rank correlation between the histological grades (according to Marsh) and FOXP3⁺ regulatory T cells cell densities (C) or between the densities of FOXP3⁺ regulatory T cells and serum IgA-tTG levels (D) in the studied persons. ^bP < 0.01, CD total vs normal mucosa; ^dP < 0.01, CD vs normal mucosa; ^fP < 0.01, CD with T1D vs normal mucosa; ^hP < 0.01, CD total vs normal mucosa; ⁱP value for CD vs CD with T1D not statistically significant. CD: Celiac disease; T1D: Type 1 diabetes; DC: Dendritic cell; IgA-tTG: IgA antibody; Tregs: regulatory T cells.