Clinicopathologic factors and molecular markers related to lymph node metastasis in early gastric cancer

doi:10.3748/wjg.v21.i2.571

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2015; 21(2): 571-577
Published online Jan 14, 2015. doi: 10.3748/wjg.v21.i2.571

Table 4 Univariate analysis of predictive molecular markers for lymph node metastasis n (%)

Lymph node metastasis	Presence	Absence	P value
Microsatellite instability			0.412
MSS	89 (90.8)	820 (90.0)
MSI-L	1 (1.0)	30 (3.3)
MSI-H	8 (8.2)	61 (6.7)
hMLH1			0.703
Negative	5 (7.4)	43 (6.2)
Positive	63 (92.6)	653 (93.8)
p53			0.773
Negative	59 (60.8)	592 (62.3)
Positive	38 (39.2)	358 (37.7)
EGFR overexpression			0.001
Negative	55 (77.5)	558 (90.1)
Positive	16 (22.5)	61 (9.9)
HER2 overexpression			0.084
Negative	33 (84.6)	263 (71.7)
Positive	6 (15.4)	104 (28.3)

MSS: Microsatellite stable; MSI-L: Microsatellite instability-low; MSI-H: Microsatellite instability-high; hMLH1: Human mutL homolog 1; EGFR: Epidermal growth factor receptor; HER2: Human epidermal growth factor receptor 2.

Citation: Jin EH, Lee DH, Jung SA, Shim KN, Seo JY, Kim N, Shin CM, Yoon H, Jung HC. Clinicopathologic factors and molecular markers related to lymph node metastasis in early gastric cancer. World J Gastroenterol 2015; 21(2): 571-577
URL: https://www.wjgnet.com/1007-9327/full/v21/i2/571.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i2.571