Thrombomodulin in the management of acute cholangitis-induced disseminated intravascular coagulation

Table 3 Factors associated with persistent disseminated intravascular coagulation (univariate analysis)

	Persistent DIC (n = 25)	Resolved DIC (n = 41)	P value	OR (95%CI)
Age (> 80 yr)	9	18	0.610	0.72 (0.26-2.0)
Female	7	16	0.431	0. 61 (0.21-1.8)
Primary disease (Malignant)	15	9	0.003	5.3 (1.8-16)
Severity of cholangitis (Severe)	23	37	1.000	1.2 (0.21-7.3)
DIC score (> 6)	12	15	0.442	1.6 (0.58-4.4)
SIRS score (> 3)	11	24	0.313	0.56 (0.20-1.5)
Without biliary drainage	14	3	< 0.001	16 (3.9-66)
Without rTM	19	17	0.010	4.5 (1.5-14)
Without AT	12	13	0.203	2.0 (0.71-5.5)
Without GM	5	17	0.107	0.35 (0.11-1.1)
Without NM	12	32	0.016	0.26 (0.088-0.76)
Without DS	22	37	1.000	0.79 (0.16-3.9)
Plt (< 80 × 103/μL)	12	24	0.452	0.65 (0.24-1.8)
FDP (> 25 μg/mL)	17	20	0.201	2.2 (0.79-6.3)
PT-INR	10	12	0.426	1.6 (0.57-4.6)
Fib (< 200 mg/dL)	7	5	0.186	2.8 (0.78-10)
CRP (> 15 mg/dL)	7	14	0.786	0.75 (0.25-2.2)
T-Bil (> 10 mg/dL)	4	3	0.412	0.49 (0.35-12)

DIC: Disseminated intravascular coagulation; SIRS: Systemic inflammatory response syndrome; rTM: Recombinant human soluble thrombomodulin; AT: Antithrombin; GM: Gabexate mesilate; NM: Nafamostat mesilate; DS: Danaparoid sodium; Plt: Platelet count; FDP: Fibrin/fibrinogen degradation products; PT-INR: Prothrombin time-international normalized ratio; CRP: C-reactive protein; Fib: Fibrinogen; T-Bil: Total bilirubin.