Butein effects in colitis and interleukin-6/signal transducer and activator of transcription 3 expression

Table 1 Histologic scores

Grade 0	Normal tissue
Grade 1	One or a few multifocal mononuclear cell infiltrates in the lamina propria
	Minimal epithelial hyperplasia
	Slight to no depletion of mucus from goblet cells
Grade 2	Lesions tended to involve more of the intestine than grade 1 lesions
	Several multifocal, mild inflammatory cell infiltrates in the lamina propria
	Mild epithelial hyperplasia and mucin depletion
	Small epithelial erosions
Grade 3	Lesions involved a large area of the mucosa or were more frequent than grade 2 lesions
	Moderate inflammation with the involvement of submucosa
	Mixture of mononuclear cells as well as neutrophils, and crypt abscesses
	Moderate epithelial hyperplasia and mucin depletion
	Ulcers were occasionally observed
Grade 4	Lesions usually involved most of the intestinal section and were more severe than grade 3 lesions
	Severe inflammation including mononuclear cells and neutrophils with transmural involvement
	Marked epithelial hyperplasia
	Crypt abscesses and ulcers