Validation of aspartate aminotransferase to platelet ratio for diagnosis of liver fibrosis and prediction of postoperative prognosis in infants with biliary atresia

Table 2 Comparison of liver injury parameters in biliary atresia patients according to aminotransferase to platelet ratio index cut-off value n (%)

Parameter	APRI for significant fibrosis (cut-off = 0.95)				APRI for cirrhosis (cut-off = 1.66)
	At KP		6 mo after KP		At KP		6 mo after KP
	≤ 0.95(n = 24)	> 0.95(n = 24)	≤ 0.95(n = 24)	> 0.95(n = 24)	≤ 1.66(n = 38)	> 1.66(n = 10)	≤ 1.66(n = 38)	> 1.66(n = 10)
AST (U/L)	194 (83)	496 (721)1	210 (188)	149 (93)	234 (92)	785 (1077)2	183 (159)	165 (102)
ALT (U/L)	136 (73)	293 (327)1	163 (128)	126 (96)	164 (100)	407 (474)2	139 (112)	168 (121)

All data are shown as mean (SD).

¹Compared with non-significant fibrosis group, P < 0.05; but it decreased to the same levels as non-significant fibrosis group. There were no obvious changes of AST and ALT in non-significant fibrosis group before and after KP.

²Compared with non-cirrhosis group, P < 0.01; but it decreased to the same levels as non-cirrhosis group. There also were no obvious changes of AST and ALT in non-cirrhosis group before and after KP. APRI: Aminotransferase to platelet ratio index.