Validation of aspartate aminotransferase to platelet ratio for diagnosis of liver fibrosis and prediction of postoperative prognosis in infants with biliary atresia

doi:10.3748/wjg.v21.i19.5893

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastroenterol. May 21, 2015; 21(19): 5893-5900
Published online May 21, 2015. doi: 10.3748/wjg.v21.i19.5893

Table 1 General characteristic of infants with biliary atresia by Metavir stage n (%)

Parameter, mean ± SD	All	Metavir stage
	(n = 91)	F0	F1	F2	F3	F4	P value
		(n = 2)	(n = 23)	(n = 35)	(n = 21)	(n = 10)
Age (d)	83 (36)	45 (37)	70 (37)	84 (22)	85 (34)	110 (62)	0.027
AST (U/L)	285 (182)	233 (259)	221 (114)	310 (230)	307 (169)	306 (125)	NS
ALT (U/L)	179 (105)	127 (152)	175 (128)	197 (104)	152 (78)	198 (94)	NS
ALP (U/L)	541 (221)	366 (235)	511 (207)	569 (220)	518 (242)	597 (225)	NS
γ-GT (U/L)	895 (685)	892 (841)	751 (632)	1009 (810)	972 (610)	662 (404)	NS
TP (g/L)	58.3 (4.8)	57.6 (13.9)	57.9 (5.7)	58.8 (4.2)	58.7 (4.0)	56.5 (4.5)	NS
ALB (g/L)	40.0 (4.7)	41.4 (3.9)	40.0 (3.8)	40.6 (5.4)	40.0 (4.2)	38.2 (5.3)	NS
TBIL (μmol/L)	202.8 (75.8)	313.5 (44.6)	192.5 (71.9)	193.5 (60)	222.5 (100.6)	195.4 (65.6)	NS
DBIL (μmol/L)	147.6 (55.2)	133.6 (92.6)	138.9 (52.9)	144.2 (41.3)	170.3 (75.6)	134.9 (43.1)	NS
TBA (μmol/L)	166.7 (68.5)	71.9 (36.9)	133.0 (53.8)	175.2 (65.6)	194.9 (64.0)	177.2 (84.5)	0.007
PLT (× 10⁹/L)	447 (162)	713 (127)	498 (126)	454 (151)	435 (155)	279 (165)	0.000
INR	1.03 (0.26)	1.69 (1.06)	1.01 (0.13)	1.00 (0.11)	1.00 (0.12)	1.18 (0.59)	0.001
AST/ALT	1.84 (1.13)	2.14 (0.52)	1.84 (1.80)	1.64 (0.65)	2.21 (1.06)	1.66 (0.52)	NS
APRI	1.28 (1.05)	0.50 (0.52)	0.79 (0.45)	1.26 (0.93)	1.35 (0.93)	2.51 (1.68)	0.000

SD: Standard deviation; NS: Not significant; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; γ-GT: Gamma-glutamyl transpeptidase; TP: Total protein; ALB: Albumin; TBIL: Total bilirubin; DBIL: Direct bilirubin; TBA: Total bile acids; INR: International normalized ratio; APRI: Aspartate aminotransferase to platelet ratio index. Reference intervals: AST (5-60 U/L), ALT (3-35 U/L), ALP (118-390 U/L), γ-GT (13-57 U/L), TP (60-80 g/L), ALB (35-50 g/L), TBIL (2-17 μmol/L), DBIL (0-7 μmol/L), TBA (0-15 μmol/L), PLT (140-440 × 10⁹/L), INR (0.8-1.5).

Citation: Yang LY, Fu J, Peng XF, Pang SY, Gao KK, Chen ZR, He LJ, Wen Z, Wang H, Li L, Wang FH, Yu JK, Xu Y, Gong ST, Xia HM, Liu HY. Validation of aspartate aminotransferase to platelet ratio for diagnosis of liver fibrosis and prediction of postoperative prognosis in infants with biliary atresia. World J Gastroenterol 2015; 21(19): 5893-5900
URL: https://www.wjgnet.com/1007-9327/full/v21/i19/5893.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i19.5893