Dihydromyricetin alleviates carbon tetrachloride-induced acute liver injury via JNK-dependent mechanism in mice

Figure 4 Dihydromyricetin reduces the expression of apoptosis-related proteins. A: The release of cytochrome c from the mitochondria into cytosol and Bax expression in the DHM group were significantly inhibited compared with the control on day 2 after CCl₄ (1 mL/kg) injection. Activities of Caspase 8 (B), Caspase 3 (C), Caspase 6 (D) and Caspase 9 (E) in the liver were markedly lower in mice of the DHM group than the control on day 2 after CCl₄ (1 mL/kg) injection. Values represent mean ± SE (n = 6). ^aP < 0.05 and ^bP < 0.01 vs control, respectively.