Systematic review and meta-analysis of prophylactic abdominal drainage after pancreatic resection

Table 5 Summary of results

Outcome of interest	Studies	Patients		Results		Pooled estimates	P value	P value for HG	I2
		No drainage	Drainage	No drainage	Drainage	(95%CI)
Mortality
Overall analysis	7	1353	1283	2.96%	1.87%	1.56 (0.93-2.62)	0.09	0.31	15%
Restricted analysis of RCTs	2	160	150	6.25%	2.56%	2.55 (0.79-8.30)	0.12	0.25	26%
Subgroup analysis of PD	5	954	911	3.35%	1.32%	2.39 (1.22-4.69)	0.01	0.52	0%
Overall morbidity
Overall analysis	9	1421	1373	43.54%	52.59%	0.69 (0.52-0.92)	0.01	0.01	58%
Restricted analysis of RCTs	2	160	150	66.88%	67.31%	1.00 (0.58-1.72)	1.00	0.26	20%
Subgroup analysis of PD	5	945	783	46.35%	51.34%	0.69 (0.56-0.84)	< 0.01	0.23	28%
Subgroup analysis of DP	2	226	193	27.88%	33.68%	1.29 (0.24-6.81)	0.76	< 0.01	89%
POPF
Overall analysis	7	1292	1234	13.78%	27.55%	0.55 (0.42-0.72)	< 0.01	0.07	46%
Subgroup analysis of PD	4	907	732	13.34%	26.23%	0.46 (0.35-0.59)	< 0.01	0.24	28%
Subgroup analysis of DP	2	226	193	16.81%	24.87%	0.39 (0.07-2.21)	0.29	0.17	46%
CR-PF
Overall analysis	6	743	694	9.02%	13.26%	0.72 (0.33-1.59)	0.42	< 0.01	69%
Subgroup analysis of PD	3	554	346	8.84%	15.32%	0.61 (0.14-2.66)	0.51	< 0.01	81%
Abdominal abscess
Overall analysis	7	414	582	11.84%	8.59%	1.29 (0.84-1.98)	0.25	0.34	11%
Restricted analysis of RCTs	2	160	150	15.00%	7.70%	1.95 (0.53-7.16)	0.32	0.09	65%
Subgroup analysis of PD	3	134	146	14.18%	6.85%	2.12 (0.95-4.72)	0.07	0.13	50%
Interventional radiology drainage
Overall analysis	8	1309	1243	11.38%	12.31%	1.05 (0.69-1.62)	0.81	0.03	52%
Restricted analysis of RCTs	2	160	150	14.38%	10.90%	1.35 (0.26-6.97)	0.72	0.02	81%
Subgroup analysis of PD	5	945	783	10.16%	12.52%	0.87 (0.65-1.19)	0.39	0.13	43%
Subgroup analysis of DP	2	226	193	18.14%	20.73%	1.03 (0.38-2.80)	0.95	0.13	57%
Reoperation
Overall analysis	9	1421	1373	4.71%	4.73%	1.01 (0.70-1.47)	0.95	0.59	0%
Restricted analysis of RCTs	2	160	150	16.67%	6.41%	1.11 (0.17-7.29)	0.91	0.07	70%
Subgroup analysis of PD	5	945	783	4.02%	2.68%	1.26 (0.73-2.17)	0.41	0.51	0%
Subgroup analysis of DP	2	226	193	3.54%	6.22%	0.80 (0.29-2.17)	0.66	0.46	0%
Length of hospital stay
Overall analysis	9	1421	1373	-	-	-0.96 [-1.74-(-0.18)]	0.02	< 0.01	92%
Restricted analysis of RCTs	2	160	150	-	-	0.78 (-0.40-1.97)	0.19	0.49	0%
Subgroup analysis of PD	5	945	783	-	-	-0.75 (-1.73-0.24)	0.14	< 0.01	85%
Subgroup analysis of DP	2	226	193	-	-	-2.10 [-2.46-(-1.73)]	< 0.01	0.29	11%

PD: Pancreaticoduodenectomy; DP: Distal pancreatectomy; RCT: Randomized clinical trial.