Association of IL-17 polymorphisms with gastric cancer risk in Asian populations

Table 2 Meta-analysis of the association between IL-17 genetic polymorphisms and gastric cancer

Subgroup analysis	W allele vs M(Allele model)			WW + WM vs MM(Dominant model)			WW vs WM + MM(Recessive model)			WW vs MM(Homozygous model)			WW vs WM(Heterozygous model)
	OR	95%CI	P value	OR	95%CI	P value	OR	95%CI	P value	OR	95%CI	P value	OR	95%CI	P value
rs2275913 G>A	1.33	1.12-1.57	0.001	1.34	1.11-1.62	0.003	1.50	1.15-1.94	0.002	1.65	1.23-2.20	0.001	1.42	1.10-1.84	0.008
Country
China	1.47	1.05-2.05	0.024	1.59	1.19-2.11	0.001	1.60	0.95-2.70	0.078	1.98	1.12-3.50	0.019	1.43	0.86-2.38	0.167
Iran	1.22	0.90-1.65	0.207	1.07	0.66-1.73	0.788	1.49	0.93-2.39	0.095	1.39	0.79-2.44	0.258	1.57	0.94-2.63	0.087
Japan	1.19	1.04-1.37	0.013	1.12	0.89-1.40	0.322	1.37	1.11-1.70	0.004	1.36	1.04-1.77	0.022	1.38	1.10-1.74	0.006
Genotyping method
PCR-RFLP	1.11	0.98-1.26	0.088	1.24	1.02-1.52	0.034	1.15	0.79-1.69	0.468	1.23	0.97-1.57	0.088	1.13	0.67-1.93	0.644
MassArray	1.72	1.48-2.00	< 0.001	1.85	1.43-2.41	< 0.001	2.06	1.66-2.56	< 0.001	2.61	1.95-3.49	< 0.001	1.83	1.45-2.32	< 0.001
PCR-SSCP	1.19	1.04-1.37	0.013	1.12	0.89-1.40	0.322	1.37	1.11-1.70	0.004	1.36	1.04-1.77	0.022	1.38	1.10-1.74	0.006
rs763780 T>C	1.95	1.47-2.59	< 0.001	1.21	0.85-1.72	0.299	2.47	1.63-3.74	< 0.001	1.54	1.15-2.05	0.004	2.83	1.63-4.91	< 0.001
Country
China	1.85	1.32-2.59	< 0.001	1.13	0.84-1.54	0.421	2.42	1.40-4.18	0.002	1.45	1.07-1.95	0.016	2.93	1.34-6.39	0.007
Japan	2.31	1.71-3.12	< 0.001	2.60	0.88-7.72	0.085	2.68	1.91-3.75	< 0.001	3.44	1.15-10.26	0.027	2.62	1.86-3.70	< 0.001
Genotyping method
PCR-RFLP	1.40	1.19-1.66	< 0.001	1.40	0.91-2.14	0.122	1.51	1.24-1.84	< 0.001	1.60	1.04-2.46	0.033	1.50	1.21-1.85	< 0.001
MassArray	2.17	1.78-2.66	< 0.001	0.94	0.62-1.41	0.759	3.14	2.45-4.01	< 0.001	1.32	0.87-1.99	0.194	4.20	3.14-5.62	< 0.001
PCR-SSCP	2.31	1.71-3.12	< 0.001	2.60	0.88-7.72	0.085	2.68	1.91-3.75	< 0.001	3.44	1.15-10.26	0.027	2.62	1.86-3.70	< 0.001

W: Wild-type allele; M: Mutant allele; WW: Wild-type homozygote; WM: Heterozygote; MM: Mutant homozygote; SNP: Single nucleotide polymorphism.