Ascites and alpha-fetoprotein improve prognostic performance of Barcelona Clinic Liver Cancer staging

Table 4 Multivariate analysis of baseline predictors of survival for each stage

Variable	BCLC A		BCLC B
	HR (95%CI)	P value	HR (95%CI)	P value
Number of tumor nodules > 1	1.82 (1.21-2.75)	0.004	-	-
Maximum tumor diameter > 5 cm	1.02 (0.49-2.13)	0.942	2.95 (1.87-4.6)	< 0.001
Elevated Child score	3.2 (2.12-4.87)	< 0.001	1.75 (1.27-2.42)	0.001
AFP ≥ 200 ng/mL	1.6 (1.11-2.32)	0.012	1.3 (1.01-1.74)	0.040
Presence of ascites	1.7 (1.16-2.66)	0.007	1.44 (1.03-2.04)	0.030

P-value < 0.05 is considered significant AFP: Alpha-fetoprotein; BCLC: Barcelona Clinic Liver Cancer; HR: Hazard ratio; CI: Confidence interval.