Significance of platelet count and platelet-based models for hepatocellular carcinoma recurrence

Table 1 Scoring of noninvasive models

Index	Formula
CLIP	Sum of:
	Child-Pugh: A = 0, B = 1, C = 2
	Tumor morphology: Uninodular and extension ≤ 50% = 0, multinodular and extension ≤ 50% = 1, massive or extension ≥ 50% = 2
	AFP: < 400 = 0, ≥ 400 = 1
	Portal vein thrombosis: no = 0, yes = 1
Pohl	Positive: AAR > 1 and PLT < 150
AARP	Positive: AAR > 1 or PLT < 150
AAR	AST/ALT
API	Sum of:
	Age (yr): < 30 = 0, 30-39 = 1, 40-49 = 2, 50-59 = 3, 60-69 = 4, ≥ 70 = 5
	PLT: ≥ 225 = 0, 200-224 = 1, 175-199 = 2, 150-174 = 3, 125-149 = 4, < 125 = 5
CDS	Sum of:
	PLT: > 340 = 0, 280–339 = 1, 220-279 = 2, 160-219 = 3, 100-159 = 4, 40-99 = 5, < 40 = 6
	ALT/AST: > 1.7 = 0, 1.2-1.7 = 1, 0.6-1.1 = 2, < 0.6 = 3
	PT: < 1.1 = 0, 1.1-1.4 = 1, > 1.4 = 2
APRI	AST × 100/PLT
FIB-4	Age × AST/PLT × ALT1/2
FibroQ	10 × Age × AST × PT/ALT × PLT
Lok	Lok index = exp (log odds)/[1 - exp (log odds)]
	Log odds = -5.56-0089 × PLT + 1.26 × AAR + 5.27 × PT
GUCI	Normalized AST × PT × 100/PLT
APGA	Log (index) = 1.44 + 0.1490 × log (GGT) + 0.3308 × log (AST) - 0.5846 log × (PLT) + 0.1148 × log (AFP + 1)
PAPAS	Log (index + 1) = 0.025 + 0.0031 × age + 0.1483 × log (ALP) + 0.004 × log (AST) + 0.0908 × log (AFP + 1) - 0.028 × log (PLT)

AAR: Aspartate aminotransferase/alanine aminotransferase ratio; AARP: AAR-platelet count score; AFP: Alpha-fetoprotein; ALP: Alkaline phosphatase; ALT: Alanine aminotransferase; APGA: Aspartate aminotransferase/platelet count/γ-glutamyl transpeptidase/alpha-fetoprotein index; API: Age/platelet count index; APRI: Aspartate aminotransferase/platelet count ratio index; AST: Aspartate aminotransferase; CDS: Cirrhosis discriminant score; CLIP: Cancer of the Liver Italian Program; FIB-4: Fibrosis index based on the four factors; FibroQ: Fibro-quotient; GGT: γ-glutamyl transpeptidase; GUCI: Goteburg University Cirrhosis Index; PAPAS: Platelet count/age/ALP/AFP/AST index; PLT: Platelet count; PT: Prothrombin time. AFP (ng/mL); Age (year); ALT (U/L); AST (U/L); GGT (U/L); PLT (10⁹/L); PT (international normalized ratio).