Expression of pyruvate dehydrogenase is an independent prognostic marker in gastric cancer

Figure 3 Correlation between pyruvate dehydrogenase expression and prognosis of gastric cancer patients. Kaplan-Meier curves for cumulative survival of patients with gastric cancer (GC) according to GC tissue pyruvate dehydrogenase (PDH) expression shows that PDH expression in GC (A), in non-neoplastic mucosa (NNM) (B) and in both GC and NNM (C) was significantly associated with better overall survival. The Kaplan-Meier curves for cumulative survival rate stratified by Lauren grade, histological type and tumor-node-metastasis (TNM) stage also show that PDH expression was significantly associated with a better overall survival in each subtype of GC: intestinal-type GC (D), diffuse-type GC (E), differentiated type GC (F), undifferentiated type GC (G), and TNM stage I (H), II (I), III (J), and IV (K) subgroups.