Expression of pyruvate dehydrogenase is an independent prognostic marker in gastric cancer

Figure 2 Relationship between pyruvate dehydrogenase expression level in cancer and non-neoplastic mucosa tissue from the same patient. The results showed that 123 patients had pyruvate dehydrogenase (PDH) co-expression (GC⁺/NNM⁺), 24 patients had GC⁺/NNM^- single expression, 76 patients had GC^-/NNM⁺ single expression, and 42 patients had double PDH negative expression; 147 cases (55.47%) showed positive PDH staining (Tumor ++ and Tumor +++) and 118 (44.53%) specimens displayed negative staining (Tumor - and Tumor +). PDH expression was much higher in the NNM tissue with positive staining in 199 (75.09%) specimens and negative staining in 66 (24.91%) specimens; P < 0.001. NNM: Non-neoplastic mucosa; GC: Gastric cancer.