Acute gastroenteritis outbreak caused by a GII.6 norovirus

Figure 1 Diagram of the genetic structure of the virus. The RNA genome is organized into three open reading frames (ORF1, ORF2, and ORF3) that encode the designated nonstructural and structural proteins. The nonstructural protein consists of p48, nucleoside triphosphatase (NTP), p22, viral genome-linked protein (VPg), 3C-like protease (3C), and RdRp. VP1, the major capsid protein, is further organized into N-terminal, shell (S), and protruding (P) domains defined by the indicated VP1 amino acid residues. VP2 is a minor structural protein. The diagnostic and genotyping primers used in the RT-PCR assay targeting conserved areas are shown in red (A-D).