Is Helicobacter pylori infection associated with glycemic control in diabetics?

Table 2 Population information of the selected studies

Ref.	DM type	Age (yr)	Sex (M/F, n)	DM duration (yr)	Type of therapy for DM	GI symptoms, n
de Luis et al[43], 2000	T1DM	44.9 ± 15.5	4/9	13.49 ± 7.0	Insulin	10 with dyspepsia
				(1-33)
Arslan et al[28], 2000	T1DM	12.6 ± 4.2	36/52	HP+: 3.85 ± 3.62;	Insulin	5 had upper GI symptoms
				HP-: 2.30 ± 2.12 (P = 0.02)1
				(0-13)
Ko et al[29], 2001	T2DM	49.9 ± 12.0	29/34	HP+: 5.2 ± 5.7;	Irrespective	29 had upper GI symptoms
				HP-: 7.3 ± 6.6 (NS)
				(1-26; median: 3)
Jones et al[30], 2002	T1DM and T2DM	44.7 ± 2.99	25/38	16.6 ± 1.4	Insulin; oral drugs	GI symptoms occurred frequently
Ojetti et al[18], 2002	T1DM	42 ± 9	18/16	NA	Insulin	None had GI symptoms
Candelli et al[31], 2003	T1DM	15 ± 6	65/56	6.6 ± 4.6	Insulin	A proportion had GI symptoms
Wang et al[32], 2003	T2DM	(28-83)	44/50	HP+: 5.8 ± 2.2;	Insulin and oral drugs	A proportion had GI symptoms2
				HP-: 9.3 ± 6.5 (P < 0.05)1
Candelli et al[33], 2004	T1DM	13.35 ± 3.62	28/30	NA	Insulin	35 had GI symptoms
Agrawal et al[38], 2005	T2DM	52.8 ± 11.1	62/18	NA	NA	36 had GI symptoms
Moghimi et al[41], 2007	T2DM	NA	NA	No difference in two groups	Insulin and oral drugs	NA
Ojetti et al[19], 2007	T1DM	48 ± 9	23/17	27.5 ± 12.5	Insulin	NA
Toporowska-Kowalska et al[34], 2007	T1DM	14.38 ± 3.75	NA	(0.5-16)	Insulin	NA
Khalil et al[44], 2007	T1DM	14.2 ± 2.8	56/44	6.2 ± 2.3	Insulin	45 had vague abdominal pain
Demir et al[35], 2008	T2DM	52.0 ± 8.2	44/97	6.1 ± 5.9	Insulin, oral drugs or diet alone	All had GI symptoms
				HP+: 5.9 ± 6.1;
				HP-: 6.28 ± 5.9 (NS)
Lu et al[40], 2010	T1DM	18.6 ± 10.6	45/35	No difference in two groups	Insulin	NA
Candelli et al[17], 2012	T1DM	16.8 ± NA (9-21)	41/28	NA	Insulin	A proportion had GI symptoms
Wei[39], 2012	T2DM	50.0 ± 11.2	36/32	NA	NA	NA
Zhou et al[36], 2012	T2DM	59.22 ± 2.57	87/93	NA	NA	NA
Vafaeimanesh et al[42], 2013	T2DM	55.3 ± 10.4	50/43	NA	Non-insulin users	A proportion had GI symptoms
Peng et al[37], 2013	T2DM	50.1 ± 10.3	51/34	No difference in two groups	NA	NA
Wada et al[45], 2013	T2DM	63.7 ± 1.1	55/17	NA	NA	NA

¹Significant difference in the duration of diabetes for the HP+ vs HP-;

²Prevalence of GI symptoms was higher in the HP+ group than in the HP- group. Data are presented as mean ± SD (range). DM: Diabetes mellitus; HP+: Helicobacter pylori–positive; HP-: H. pylori–negative; GI: Gastrointestinal; NA: Not available; NS: Not significant; T1DM: Type 1 diabetes mellitus; T2DM: Type 2 diabetes mellitus.