Radiofrequency ablation for single hepatocellular carcinoma 3 cm or less as first-line treatment

Table 2 Significant variables for overall survival in the univariate and multivariate analyses (n = 184)

Significant variable	Univariate analysis		Multivariate analysis
	OR (95%CI)	P value	OR (95%CI)	P value
Age (> 65 yr), yes/no	1.141 (0.735-1.724)	0.034	1.057 (0.787-1.587)	0.097
Gender (male), yes/no	0.980 (0.545-1.763)	0.947
Tumor size (> 2.0 cm/ ≤ 2.0 cm)	1.001 (0.754-1.328)	0.994
Child-Pugh grade (class A/B)	0.976 (0.438-2.177)	0.954
AFP (> 20 ng/mL/ ≤ 20 ng/mL)	1.031 (0.726-2.041)	0.342
Hepatitis B (yes/no)	1.070 (0.557-2.054)	0.839
Hepatitis C (yes/no)	0.596 (0.252-1.412	0.240
Hepatitis B and C (yes/no)	0.596 (0.252-1.412)	0.240
Portal hypertension (yes/no)	2.847 (1.819-4.458)	0.015	2.089(1.387-2.958)	0.027
Total bilirubin (< 1.5 mg/dL/≥ 1.5 mg/dL)	3.023 (1.632-5.600)	0.006	1.556 (1.827-2.965)	0.028
Approach of the first ablation session (laparoscopic) (yes/no)	1.205 (0.678-2.231)	0.068