Reversibility and heritability of liver fibrosis: Implications for research and therapy

Table 1 Summary of studies evaluating DNA methylation in liver fibrosis

Ref.	Model	Findings
Komatsu et al[23]	Mouse, early fibrosis (2 wk CCl4)	global and Spp1 promoter hypomethylation
Tao et al[17]	Rat (12 wk CCl4) and HSC-T6 cell line	5-aza-2’-deoxycytidine inhibited HSC proliferation and blocked the decreased expressions of RASAL1
Mann et al[24]	Rat (5 wk CCl4) HSC and human HSC line	5-aza-2’-deoxycytidine blocked HSC transdifferentiation and prevented loss of PPARγ expression
Zeybel et al[12]	Human NAFLD	PPARγ promoter hypermethylation in severe more than mild fibrosis
Oh et al[25]	Human cirrhotic and HCC tissues	Increased DNMT3a mRNA and hypermeyhylated cell cycle and tumor suppressor genes in cirrhotic but less than in HCC tissues

NAFLD: Non-alcoholic fatty-liver disease; HCC: Hepatocellular carcinoma.