Hepatitis B virus preS1 deletion is related to viral replication increase and disease progression

Table 5 Comparison of clinical data between subjects of cohort I and II with and without deletion variants n (%)

Clinical factor	Cohort I			Cohort II
	Wild type (n = 192)	Deletion (n = 72)	P value	Wild type (n = 49)	Deletion (n = 28)	P value
Age in years, mean ± SD	46.3 ± 15.7	44.7 ± 17.8	0.471	35.8 ± 8.9	39.1 ± 11.1	0.186
Male	148 (77.1)	52 (72.2)	0.423	20 (40.8)	16 (57.1)	0.235
HBeAg-positive	98 (51.0)	54 (75.0)	< 0.001	29 (69.2)	26 (92.9)	0.002
Liver disease (C : CH : LC : HCC)	43 : 27 : 47 : 75	20 : 6 : 12 : 34		18 : 31	9 : 19
ALT [IU/liter (mean ± SD)]	87.7 ± 182.4	54.4 ± 33.5	0.295	125.5 ± 271.2	120.9 ± 160.3	0.935
Median of HBV-DNA (range)	797.7 (0-6000)1	1678.9 (0-6000)1	0.013	8.3 × 108 (100-10.1 × 109)2	2.2 × 109 (2.3 × 103-15.1 × 109)2	0.049

¹Median level of HBV-DNA, pg/mL;

²Median level of HBV-DNA, copies/mL. C: Carrier; CH: Chronic hepatitis; LC: Liver cirrhosis; HCC: Hepatocellular carcinoma; HBeAg: Hepatitis B virus e antigen; ALT: Alanine aminotransferase.