Hepatitis B virus preS1 deletion is related to viral replication increase and disease progression

doi:10.3748/wjg.v21.i16.5039

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Apr 28, 2015 (publication date) through Feb 12, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Evidence-Based Medicine

World J Gastroenterol. Apr 28, 2015; 21(16): 5039-5048
Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.5039

Table 1 Clinical data of the subjects in cohort I (292 subjects) and cohort II (90 subjects) n (%)

Clinical factor	Cohort I	Cohort II
Patient No.	292	90
Age in years, mean ± SD	46.8 ± 16.0	37.8 ± 9.6
Male	225 (77.1)	46 (51.1)
HBeAg-positive	162 (55.5)	58 (64.4)
Liver disease No.	C : CH : LC : HCC	C : CH
	66 : 33 : 67 : 126	36 : 54
ALT [IU/liter (mean ± SD)]	77.7 ± 153.4	117.4 ± 226.5
Median of HBV-DNA (range)	979.4 (0-6000)¹	1.3 × 10⁹ (100-15.1 × 10⁹)²

¹Median of HBV-DNA: pg/mL;

²Median of HBV-DNA: copies/mL. C: Carrier; CH: Chronic hepatitis; LC: Liver cirrhosis; HCC: Hepatocellular carcinoma; HBeAg: Hepatitis B virus e antigen; ALT: Alanine aminotransferase; IU: International unit.

Citation: Lee SA, Kim KJ, Kim H, Choi WH, Won YS, Kim BJ. Hepatitis B virus preS1 deletion is related to viral replication increase and disease progression. World J Gastroenterol 2015; 21(16): 5039-5048
URL: https://www.wjgnet.com/1007-9327/full/v21/i16/5039.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i16.5039