Prognostic roles of preoperative α-fetoprotein and des-γ-carboxy prothrombin in hepatocellular carcinoma patients

Table 3 Univariate and multivariate analyses of factors associated with poor overall survival in patients with hepatitis B virus infection

Variables	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
Age	0.996	0.964-1.028	0.797
Sex, male	1.440	0.511-4.056	0.490
Preoperative laboratory values
Aspartate transaminase	1.008	1.002-1.014	0.0121	1.004	0.992-1.016	0.518
Alanine transaminase	0.992	0.976-1.007	0.296
Platelets	1.015	0.994-1.035	0.158
Serum ALB	0.469	0.234-0.939	0.033
PT	0.975	0.950-1.000	0.051
Serum TBIL	2.249	1.125-4.495	0.0221	1.584	0.447-5.613	0.476
ICGR15	1.056	1.025-1.087	< 0.0011	1.040	0.976-1.108	0.229
Tumor markers
HH group	2.985	1.259-7.075	0.0131	2.274	0.698-7.403	0.173
HL group	2.112	1.054-4.232	0.0351	1.025	0.390-2.693	0.960
Intraoperative data
Blood loss	1.001	1.001-1.001	< 0.0011	1.000	1.000-1.001	0.391
Surgical duration	1.004	1.001-1.008	0.0051	1.002	0.996-1.007	0.534
Pathologic results
Tumor size	1.239	1.133-1.356	< 0.0011	1.127	0.969-1.310	0.122
Multiple tumors	1.385	1.121-1.711	0.0021	1.200	0.813-1.772	0.358
Vascular invasion	2.491	1.335-4.647	0.0041	3.173	1.352-7.447	0.0081

¹Represents statistical significance. HH group: Alpha-fetoprotein values > 529.8 ng/mL and des-gamma-carboxy prothrombin values > 60 mAU/mL; HL group: Alpha-fetoprotein values > 529.8 ng/mL or des-gamma-carboxy prothrombin values > 60 mAU/mL. ALB: Albumin; PT: Prothrombin; TBIL: Total bilirubin; ICGR15: Indocyanine green retention rate at 15 min.